Oral Propylparaben Administration to Juvenile Male Wistar Rats Did Not Induce Toxicity in Reproductive Organs
نویسندگان
چکیده
منابع مشابه
Oral propylparaben administration to juvenile male Wistar rats did not induce toxicity in reproductive organs.
Parabens are in widespread use as preservatives in drugs. In the late 1990 s, concerns were raised about their capacity to disrupt endocrine function based on in vitro data and in vivo uterotrophic tests. Studies in juvenile male rats provided conflicting results on pospubertal sperm production. In an exploratory pharmacokinetic study, Wistar male rats received a single dose of propylparaben (P...
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Caffeine was investigated for its possible fetal programming effects on reproductive function of male offspring. Sixty-five pregnant Wistar rats were grouped into four. Group 1 was control and received distilled water. Groups 2, 3 and 4 were treated orally with 1.14, 3.42 and 5.70 mg/kg body weight of caffeine respectively. Each group was subdivided into four based on gestation days (GD) 1-7, 8...
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Nitrofurazone (NF) has been previously demonstrated to induce testicular toxicity with 4 weeks of oral administration in rats, ln the present study, rats were administered NF to assess whether testicular toxicity becomes evident with a 2-week administration period, Male Sprague-Dawley rats were administered oral doses of NF at 50 mgfkg fbr 2 or 4 weeks. Another group was administered NF at 100 ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2013
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kft211